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Notably, a BBA64 innate immune evasion function is inconsistent with our previous finding that intradermal needle-inoculated bba64 mutants are capable of establishing an infection in mice [33].
Indeed, pUL135 functioned even more effectively as an NK evasion function when the talin-interacting domain was deleted.
In a systematic screen, we identified UL135 as a third NK cell evasion function within UL/ b'.
pUL135 is an extremely effective NK and T cell evasion function, which operates against the background of a number of other HCMV encoded immune evasins.
By preventing the establishment of a cytotoxic synapse, the viral evasion function suppressed a wide range of effector cell types and functions.
This HCMV NK evasion function implies that the actin cytoskeleton in target cells plays a key role in IS formation and proposes another mechanism by which infectious agents can evade immune recognition.
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However, they did not distinguish lytic from latent infection, made no comparison of K3- and K3+ viruses, and did not establish whether the virus they used even retained K3-such immune evasion functions are frequently lost with in vitro passage.
Analysis of genes known to play a role in neutrophil evasion functions displayed differential expression (Additional file 10: Table S8).
A high level of sequence variation is present in HCMV clinical isolates and cultured strains, although it is not evenly distributed throughout the genome, and this variability has been shown to impact immune evasion functions (Prod'homme et al., 2012).
Other than the suggested role of immune evasion, no function has been demonstrated for these Vmps, which occur in two size classes, the variable large proteins (Vlps) and the variable small proteins (Vsps) (49 ).
The virulence of CA-MRSA may in part be related to its ability to produce toxins, such as Panton-Valentine leukocidin (PVL) which has an unique ability to kill leukocytes [ 2], resulting in bacterial evasion of bactericidal function of leukocytes [ 4].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com