Besides distinguishing subtypes within one disease, some of these features may also reflect global disease activity and thus be valuable candidates for evaluation as surrogate markers in trials of new, targeted therapies in autoimmune arthritis.
As none of the HLA class II alleles showed significant positive or negative association with the exception of Cw*06, this result is presented here to allow others to consider the evaluation of this issue in trials of IFN-α2b that are being conducted in separate US and European cooperative groups.
To do so, we adapted the clinical composite (which has been validated in trials of chronic HF) to the evaluation of IV levosimendan in a pilot trial of acute decompensated HF (REVIVE-1).
Combinations of advice and motivational interviewing are a promising target for evaluation in trials, and more detailed studies of the conduct of brief interventions are needed.
She has expertise in the economic evaluation alongside trials of complex public health and psychosocial interventions, and an interest in the health economics of disability.
Repeated calls for theoretically sound process evaluations in randomized controlled trials of complex interventions, and policy-makers who call for a proper understanding of implementation processes, emphasize the value of conceptual tools like the Normalization Process Model.
Repeated calls for theoretically sound process evaluations in randomized controlled trials of complex interventions [ 2, 4, 25], and policy-makers who call for a proper understanding of implementation processes [ 26], give emphasis to the value of conceptual tools like the Normalization Process Model.
At present there is no international expert consensus regarding measures for assessment of disease activity, severity, damage or outcome in pSS that can be used in the evaluation of clinical trials of new therapies and longitudinal observational studies.
The time schedule of these evaluations in the trial is shown in Table 2.
