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For example, the Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation (PERISCOPE) trial compared the effects of treatment with pioglitazone or glimepiride for 18 months on plaque volume in 543 patients with coronary disease and type 2 diabetes [ 8].
In the Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation (PERISCOPE) study (26), coronary intravascular ultrasonography was used to assess the change in percent atheroma volume in 360 patients with T2DM and coronary artery disease treated with either pioglitazone or glimepiride.
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12 PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) is a randomized, double-blind, multi-center study, whose results have been recently published, which involved 543 subjects with coronary disease and type 2 diabetes mellitus.
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