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The aim of this study was to investigate the skin tolerability and product acceptability of a new ABHR (EVO9; Ecolab) in healthcare workers under daily working conditions and to evaluate the practicability of the WHO protocol "Method 1 for evaluation of tolerability and acceptability of alcohol-based hand rub in use or planned to be introduced" (WHO 2009).
In all these studies evaluation of tolerability and quality of life is as relevant as efficacy results.
On the other hand, although the evaluation of the quality of life (QOL) was recently determined to be important in the evaluation of tolerability, we did not collect data on the QOL in the present study.
The methodology was based on the published WHO protocol "Method 1 for Evaluation of tolerability and acceptability of alcohol-based hand rub in use or planned to be introduced" [ 13].
During the remainder of the study, the patient's dose could be adjusted up to 60 mg BID or down to 40 mg BID, based upon the physician's clinical evaluation of tolerability and efficacy.
35 The secondary objectives include assessing the optimal dose of telmisartan that can significantly reduce insulin resistance, evaluation of tolerability of telmisartan in HIV patients and mechanistic evaluation of the metabolic effects of telmisartan.
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The decision to continue the study or not depended on evaluations of tolerability, safety and pharmacokinetic profile of cyclophosphamide after 6 weeks.
The secondary objectives of the studies were to avoid postponement of further planned cancer chemotherapy and to describe and evaluate subjective and objective symptoms and signs following dexrazoxane treatment, as well as evaluation of the tolerability and/or toxicity of dexrazoxane.
Secondary end points were evaluation of toxicity, tolerability and alterations in levels of circulating growth factors.
The clinical significance of these findings remains to be determined, along with careful evaluation of the tolerability of mTOR inhibitor chemotherapy combinations.
Confirmed VL rebound should prompt a careful evaluation of regimen tolerability, drug-drug interactions, resistance and patient adherence.
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