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Furthermore, the Ki-67 assay has been used as a reputed method for the evaluation of the proliferative state of hMSCs [26, 27].
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Evaluation of the tumour proliferative activity is frequently assessed by immunohistochemistry, using the expression of Ki-67 nuclear antigen [ 20], a nuclear non-histone protein present exclusively in proliferating cells, whether they are normal or neoplastic [ 21].
Fig. 3 In vitro evaluation of the anti-proliferative efficacy of micelles.
To predict the prognosis of MM patients, the evaluation of cellular proliferative activity is regarded with great importance.
Splenocytes were isolated from the remaining half of spleen for evaluation of their proliferative response to mitogen challenge in vitro.
Evaluation of proliferative potential of ameloblastomatous epithelium in the cystic lining reflects the tumor behavior and tendency towards recurrence [ 9].
We presented here a new approach to the evaluation of chemotherapy using a mathematical model to interpret the time courses of tumour mass during treatment, including measures of the proliferative activity by Ki67.
Furthermore, we performed in depth evaluation on the regulatory role of two prostate cancer-risk loci and provided strong evidence showing essential role of RGS17 for the maintenance of the proliferative potential of tumor cells43,44.
Tumors of the proliferative subtype had high levels of genomic instability, TP53 mutations, and DNA hypomethylation.
However, those cases had remaining areas of proliferative disease in both core and excision biopsies that permitted evaluation of the effects of pasireotide.
Evaluation of the young team.
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