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As another evaluation of the predictive performance of the pan-specific approach we performed a simulated "blind" leave-one-out validation.
[ 67] Explanation For the evaluation of the predictive performance there might be subgroups in which the risk model performs better than in the initial study population, and there might be genetic variants that jointly have a larger impact on disease risk.
Evaluation of the predictive performance of the three models using the bladder cancer dataset was performed via time-dependent receiver operator characteristic (ROC) curves and bootstrap.632+ prediction error curves (to assess prediction performance improvement by including selected genes over a pure clinical model) [6].
Here we report the results of the first external evaluation of the predictive performance of both models.
As more reliable information begins to emerge on alleles influencing drug response from larger, better designed whole genome and candidate gene studies, focus will need to shift to the critical evaluation of the predictive performance of genetic tests in clinical practice, including studies of cost-effectiveness.
Evaluation of the predictive performance of PBPK modeling techniques is an area that lacks consistency within the literature.
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To take clustering into account in the model evaluation, we assessed the predictive performance in individual anesthesiologists (within cluster performance).
The modeling procedure includes characterization of the population being studied, identification in advance of dependent or outcome variables and independent or risk factors, specification of the modeling plan including univariate and multivariate analyses, evaluation of the model predictive performance, and the procedure for validation of the model.
In general, the predictive performance of the model increased after performing data sampling.
The predictive performance of such a simple risk score will be compared with the predictive performance of the PIAMA Risk Score.
[ 36] "Evaluation of model predictive performance using the same dataset used for fitting the model usually leads to a biased assessment.
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