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Our results also provide a rationale for clinical evaluation of the combinations of bortezomib and oridonin (or other inhibitors of NF-κB1/2) or AD 198 (or other drugs targeting c-Myc) in the treatment of lymphoma and MM, especially in patients containing TRAF3 deletions or relevant mutations.
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These points are considered the optimal score and rank combination, respectively, and are used for evaluation of the combination result.
Subsequent evaluation of the combination in thyroid cancer is warranted.
These data provide a rationale for further evaluation of the combination of Wee1 and Chk1/2 inhibitors in malignant melanoma.
Further evaluation of the combination of chemotherapy and radiotherapy may be useful in this poor prognosis group.
Initial evaluation of the combination was carried out in the AML cell lines MV4-11, HL60 and PL21.
A phase 2 evaluation of the combination is ongoing in pediatric malignancies, neuroendocrine tumors, and breast cancer.
The results of this phase I study allowed further evaluation of the combination of aflibercept with pemetrexed and cisplatin in a phase II study.
As ALT is a component of the FibroSURE score, evaluation of the combination of ALT and inflammation as assessed by FibroSURE would not improve the diagnostic performance.
This hypothesis was tested in the MAPT -and ER-positive cell lines (MCF-7 and ZR75-1), with evaluation of the combination treatment using the Combination Index.
Thus the pre-clinical evaluation of the combination of these two clinically active agents would determine whether the combination could be worth clinical exploration.
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