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Exact(20)
These points are considered the optimal score and rank combination, respectively, and are used for evaluation of the combination result.
Subsequent evaluation of the combination in thyroid cancer is warranted.
A phase 2 evaluation of the combination is ongoing in pediatric malignancies, neuroendocrine tumors, and breast cancer.
Initial evaluation of the combination was carried out in the AML cell lines MV4-11, HL60 and PL21.
These data provide a rationale for further evaluation of the combination of Wee1 and Chk1/2 inhibitors in malignant melanoma.
Further evaluation of the combination of chemotherapy and radiotherapy may be useful in this poor prognosis group.
Similar(40)
Our results also provide a rationale for clinical evaluation of the combinations of bortezomib and oridonin (or other inhibitors of NF-κB1/2) or AD 198 (or other drugs targeting c-Myc) in the treatment of lymphoma and MM, especially in patients containing TRAF3 deletions or relevant mutations.
The further evaluation of this combination should include an examination of the medical history at the patient level as well as an analysis of similar drugs, such as other SSRIs.
In addition, there has also been no economic evaluation study of the combination of CHB treatments according to the current clinical practice guidelines on the management of CHB drug resistance until now.
The further evaluation of this combination therefore is not warranted.
Secondary end points are the study of pharmacokinetics and the antitumor activity evaluation of the experimental combination.
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