The sensitivity of TDE at rest in our study was higher and this might be because the DETECT study presented a "real-world" echocardiographic assessment without clear pre-evaluation of investigators and training of this method.
There was a good correlation of the histological evaluation of both investigators (r = 0.88; p < 0.001) for all four parameters together.
Effective recruitment strategies and the anticipation of problems are key issues in the planning and evaluation of trials by investigators, Clinical Trial Units, RECs and funding agencies.
Although the BEST study did not confirm the mortality advantage of bucindolol over placebo (Beta-Blocker Evaluation of Survival Trial Investigators 2001), there was once again no difference in outcomes between elderly (>65 years) and younger patients.
Similarly, bucindolol, a partial agonist at beta-1 receptors (Andreka et al 2002), showed no overall benefit on mortality in patients with chronic heart failure in the BEST study (Beta-blocker Evaluation of Survival Trial Investigators 2001).
An investigator bias is possible, as particularly the "soft" categories were subject to the personal evaluation of the principal investigator with support from a medical data assistant student.
In addition, this initial study did not include an evaluation of the perceptions of investigators and research staff related to the tool or an examination of how it might be used in other real-world settings as an adjunct to other tools; such studies are planned.
We are currently designing structured usability experiments following [32, 33]>] for evaluation of specific CrimeFighter Investigator features.
In a recent article in Next Wave's Postdoc Network, HHMI President Tom Cech argues that mentorship should be included in the evaluation of a principal investigator's productivity.
We strongly recommend that, in preparation for assuming these responsibilities, he receive a full medical and neuropsychiatric evaluation by an impartial team of investigators.
In preparation for our OpenNotes demonstration and evaluation, we convened a team of investigators from across the U.S., including three (SR, JR, and TD) who had expertise in patient access to medical records and, specifically, doctors' visit notes.
