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Section 3 introduces the proposed methodology and aspects of feature sets evaluation.

Third, the evaluation is transparent since the classification accuracy was examined as a function of feature set size (from top one to ten pathways, ranked by t-test on pathway-level aggregated data), instead of at a fixed arbitrary number of features, or an optimized number of features that results in the best performance in the validation dataset [ 8].

After the evaluation of each feature set in isolation we combined these sets step wise and evaluated their combined performance (Table 4).

During each evaluation of a feature set, the SVM model parameters were chosen by grid search.

Evaluation performance per feature set (1 Rule-based features; 2 Statistical features; 3 Scaling features; 4 Language-dependent features; 5 Length features; 6 Word type features).

Evaluation performance per feature set (1 Language features; 2 Rule-based features; 3 Text format features; 4 Word length features; 5 Right context word type features; 6 Word type features; 7 Abbreviation feature).

Evaluation performance combining feature sets stepwise according to their stand alone performance (1 Language features; 2 Rule-based features; 3 Text format features; 4 Word length features; 5 Right context word type features; 6 Word type features; 7 Abbreviation feature).

Evaluation performance combining feature sets stepwise according to their stand alone performance (1 Rule-based features; 2 Statistical features; 3 Scaling features; 4 Language-dependent features; 5 Length features; 6 Word type features).

Hence a proper systematic evaluation of a new feature set is essential.

After the mRMR feature evaluation, a ranking feature set is obtained.

The evaluation of features is a delicate issue in feature generation, as it is well-known that good individual features may not form a good feature set when they are combined with others, due to feature interaction.

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