Sentence examples for evaluation of compounds from inspiring English sources

These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies.

For computational methods it is more difficult to study selectivity than activity because selectivity analysis requires the evaluation of compounds binding to multiple targets [2].

However, the in-depth analysis of the structural features and the drug-likeness evaluation of compounds identified in TCMs are still lacking.

We present the design, synthesis and biological evaluation of compounds containing a 2- benzylidene)hexanoic acid scaffold as multi-target directed γ-secretase-modulators.

Evaluation of compounds for cell proliferation identified active compounds 11b, 11d and 11h against MCF7, MDA-MB-231 and A549 cell lines.

Moreover, in vivo evaluation of compounds 6 and 10 proved their capability to normalize the blood picture in comparison to 5-FU, a well known anticancer drug.

These data can be used to define sets of rules for the evaluation of compound toxicity.

Herein, a sensitive and rapid HPLC MS/MS quantitative method was developed and validated for the further pharmacokinetic evaluation of compound 3 in rats.

In addition, biological evaluation of compound 4 showed that it displays significant antitumor activities in FGFR1-amplificated H1581 and FGFR2-amplificated SNU-16 xenograft models.

Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound 1c from this series in a model of dyslipidemia demonstrated positive effects on plasma lipid endpoints in vivo.

Pharmacokinetic evaluation of compound 28 in mice revealed good brain penetration, as well as good clearance, half-life, and volume of distribution which collectively support the continued development of this class of compounds.