Sentence examples for evaluation of compound from inspiring English sources

In addition, biological evaluation of compound 4 showed that it displays significant antitumor activities in FGFR1-amplificated H1581 and FGFR2-amplificated SNU-16 xenograft models.

Herein, a sensitive and rapid HPLC MS/MS quantitative method was developed and validated for the further pharmacokinetic evaluation of compound 3 in rats.

Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound 1c from this series in a model of dyslipidemia demonstrated positive effects on plasma lipid endpoints in vivo.

The evaluation of compound 16 to determine its mechanism of action was performed with topo IIα-DNA cleavable complex, topo IIα-mediated ATPase assay, DNA unwinding and in vitro and ex vivo topo IIα relaxation assay.

The poor solubility of Form B resulted in a significant reduction in the oral exposure from a nanosuspension to a level that was insufficient for toxicological evaluation of compound 1.

Pharmacokinetic evaluation of compound 28 in mice revealed good brain penetration, as well as good clearance, half-life, and volume of distribution which collectively support the continued development of this class of compounds.

Yannuzzi, N. A. et al. Evaluation of compounded bevacizumab prepared for intravitreal injection.

Franzblau, S. G. et al. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.

These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies.

Evaluation of compounds for cell proliferation identified active compounds 11b, 11d and 11h against MCF7, MDA-MB-231 and A549 cell lines.

We present the design, synthesis and biological evaluation of compounds containing a 2- benzylidene)hexanoic acid scaffold as multi-target directed γ-secretase-modulators.