Patients who underwent brain MRI for the evaluation of delirium or coma while in the adult medical or surgical ICUs were identified through an institutional database.
In summary, clinical evaluation of a pentobarbital coma is difficult; barbiturate blood levels may not be reliable and continuous full-channel EEG monitoring is not feasible in many centres, as in ours.
There have been many methods proposed for evaluation and prediction of patients' neurologic outcome and prognosis, such as evaluation of the Glasgow Coma Scale or brain stem function after return of spontaneous circulation (ROSC), or measurement of serum biomarkers [ 3, 4] such as neuron-specific enolase, S100, serum ammonia [ 5] or serum lactate.
AOR: adjusted odds ratio; ARF: acute respiratory failure; BMI: body mass index; BSE: bedside swallow evaluation; CVA: cerebrovascular accident; DOSS: Dysphagia Outcome and Severity Scale; ED: emergency department; FEES: flexible endoscopic evaluation of swallowing; GCS: Glasgow Coma Scale; SOFA: Sequential Organ Failure Assessment; VFSS: videofluoroscopic studies of swallowing.
In 128 septic and sedated patients, we studied brain dysfunction including delirium and coma by the evaluation of Richmond Agitation Sedation Scale (RASS), the Confusion Method Assessment in the ICU (CAM-ICU) after sedation withdrawal and the measurement of serum S100B biomarker of brain injury.
Scoring system rates level of coma on a scale ranging from 4 (extreme) to 0 (no coma).
Among the 3 groups, no significant differences were present in Glasgow Coma Scale score, length of coma, or time since brain injury.
The thing is that there are different kinds of coma.
Thirty-three patients had electroencephalography within 72 hours after the onset of coma.
Extracellular peptide signaling is used to coordinate the activity of ComA with population density.
