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Based on the complexity of the responses of the brain to trauma, a recent National Institutes of Health working group on TBI recommended either combination therapies or the evaluation of agents that act on multiple mechanisms be evaluated as treatment options for TBI [7].
This has led to the clinical evaluation of agents that inhibit complement activation in patients with complement-mediated kidney disease.
The ability to establish an animal model with varying degrees of joint inflammation would allow evaluation of agents or conditions that could modulate the severity of the disease.
This report supports a new paradigm for rapid intermediate evaluation of agents prior to or after early human trials as a means to creating a more informed and optimal cancer drug development pathway.
In summary, these findings provide preclinical evidence supporting further evaluation of agents such as DMAPT and gemcitabine for the prevention and treatment of pancreatic cancer.
These findings have laid the basis for the clinical evaluation of agents targeting VEGF signaling pathway in patients with ovarian cancer.
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Thus, for x, peering with agent y i may impact the evaluation of agent y j.
Our results have implications for the design and evaluation of agent dialogue-game protocols.
It is reasonable to assume that results presented here can be generalised to evaluations of agents such as axitinib, that have similar mechanisms of action to the therapies included in this analysis (Rugo et al, 2005; Rini et al, 2007; Rixe et al, 2007).
Since the analysis was confined to the evaluation of chemotherapeutic agents only, trials investigating targeted agents such as metalloproteinase inhibitors, tipifarnib, erlotinib, bevacizumab or cetuximab were not included.
Evaluation of pharmacological agents showed comparable PFS probabilities after NSAIDs and hormonal agents including combination of both medicines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com