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More recently, the evaluation in mice of a novel domain III-capsid chimaeric protein expressed in E. coli provides additional evidence for a crucial role of cell-mediated immunity in protection against dengue virus [ 242– 242].
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Featured among the selected clones with b9 allotype is a rabbit/human Fab that binds with a dissociation constant of 1 nM to both human and mouse Tie-2, which will facilitate its evaluation in mouse models of human cancer.
No sign of toxidrome were observed during in vivo toxicity evaluation in mice at 300 mg/kg concentration.
Histological evaluation in mouse epidermis after daily application of nanoparticulate tretinoin cream for 4 days revealed more than double increase in epidermal thickness than conventional tretinoin vaseline preparation.
Finally, these experiments suggest that isradipine is a more potent and less toxic alternative to nimodipine for treating the neurotoxic effects of amyloid peptides, justifying a more comprehensive evaluation of its effects in mouse models of AD as a prelude to clinical trials.
In vivo evaluations were performed in mice after intraperitoneal administration of zidovudine drug solution, uncoated and coated formulation.
(iii) Behavioural and electrophysiological evaluation of synaptic plasticity in mice with conditional knockout of proteins with specific roles in mitochondrial motility (Drp1, Mfn1/2 and OPA1) and biogenesis (PGC1α and TFAM).
This is the first study to extensively analyze PPE-induced lung emphysema in mice with evaluation of the effects of DEP.
A future perspective is the evaluation of the efficacy of αT2ib in mouse models of chronic infections.
The evaluation of the radioligands in mice revealed a favorable tumor accumulation of 44Sc-PSMA-617 already shortly after injection and a relatively fast clearance of background activity through the kidneys (Fig. 4).
These compounds are undergoing further evaluation in hamster and mouse models of disease.
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