In addition, biomarker evaluation and discovery necessitates the analysis of large sample sizes to ensure statistical reliability (Koulman et al. 2009); thus, the analytical methods applied must have a high throughput.
We draw on the widely accepted definition of entrepreneurship proposed by Shane and Venkataraman (2000, p.218) in their seminal paper: 'the processes of discovery, evaluation, and exploitation of opportunities; and the set of individuals who discover, evaluate, and exploit them'.
That is, their businesses demonstrated the discovery, evaluation and exploitation of novel opportunities, such as addressing customers that were not currently served (exploitation) or developing new products or services (discovery).
A 'holy grail' of translational biomarkers with respect to drug-induced liver injury (DILI) will be the discovery, evaluation, and qualification of those that provide accurate prognoses regarding individuals that will go on to experience liver failure from those that recover given modest increases in ALT, AST and total bilirubin (TBL).
That means the presence of unpredictable environment also influence the discovery, evaluation, and exploitation of new opportunities by firms.
Entrepreneurial engagement involves the discovery, evaluation, and exploitation of opportunities by individuals (Sarason et al. 2006; Shane and Venkataraman 2000; Lim et al. 2016).
On the other hand, a more scholarly approach focuses on activity that involves the discovery, evaluation, and exploitation of opportunities to introduce new goods and services, ways of organizing, markets, process, and raw materials through organizing efforts that previously had not existed (See for instance, Shane and Venkataraman, 2000, Academy of Management Review).
Research (R) Research courses encourage students to become active participants in the discovery, critical evaluation, and application of knowledge.
Such a rich setting provides students with opportunities to become involved in a community of learning and to engage in the process of discovery and move beyond being the passive recipients of knowledge that is transmitted to being an active participant in the discovery, critical evaluation, and application of knowledge and understanding.
Extensive clinical evaluation led to the discovery of splenomegaly and retroperitoneal lymphadenopathy.
Moreover, as they appear to mimic the clinical observations of shared cross-resistance between CDDP, CBDCA and CHIP, they may represent valuable preclinical evaluation models for the discovery of drugs capable of conferring responses in CDDP-refractory ovarian cancer.
