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Here, we clarify the design of our evaluation and discuss the implications of the results of the first round for the final evaluation after completion of two screening rounds.
For patients with an objective response including CR, good PR, and PR at the first evaluation after completion of CRT, two additional cycles of adjuvant chemotherapy with S-1 plus CDDP at the same dose level during CRT were repeated with a 4-week interval starting 4 weeks after the completion of CRT.
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ICAS grew out of a strong interest expressed by the participants to proceed with further evaluations after completion of the earlier FALSIRE II project.
The evaluation team met after completion of all field interviews to formulate general conclusions from the interview material.
All patients underwent a pre-treatment MRI for primary tumour staging and a second, restaging MRI for response evaluation 6 8 weeks after completion of CRT.
Post-evaluation after the completion of the second session additionally contained an overall evaluation of the course.
Axillary MRI evaluation with high PPV could further induce two pathways when extended nodal disease is observed: axillary lymph node dissection or neoadjuvant systemic therapy and re-evaluation using MRI after completion of all chemotherapy cycles.
Patients will undergo clinical and staging re-evaluation 2 3 weeks after completion of the neoadjuvant regimen and surgical resection will be performed 3 6 weeks after the completion of neoadjuvant chemotherapy.
Supporting this, the prognostic value of a complete metabolic response on qualitative evaluation of FDG PET after completion of chemotherapy has also been demonstrated in lymphoma [ 12].
A qualitative evaluation will be undertaken after completion of the exercise programme.
An interval evaluation will be conducted after completion of INCT in Arm 1, and after completion of CRT in Arm 2 (Fig. 1).
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