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Statistical models evaluating the requirement to treat (cumulative logit model) or the suppression of c-day 11 parasitemia (GLM) showed that both adjuvant (FA superior to ISA-720) and antigen (coli42-FVO superior to bv42-FVO) affected the induction of protective effects against erythrocytic stage FVO strain P. falciparum.
In studies evaluating the requirement for cell proliferation during plasma cell differentiation, activated B cells were γ-irradiated (700 Rads) on day 4 prior to the initiation of the second culture.
It would be time consuming to cross APP-/ and agrin-/ mice, but the authors could already evaluate the implication of APP and APLP2 in the initial steps of neuromuscular junction formation by evaluating the requirement of these proteins for the prepatterning of AChR clusters that precedes nerve-muscle contact, i.e., by analyzing muscle prepatterning in APP-/ and APLP2-/ mice.
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The strengths of our study include that it is the first to investigate organ-specific manifestations associated with common sepsis infection sites (respiratory, intra-abdominal and bloodstream) by quantifying Sequential Organ Failure Assessment (SOFA) scores and evaluating the requirements for organ support in the intensive care unit.
The strengths of our study include that it is the first to investigate organ-specific manifestations associated with common sepsis infection sites (respiratory, intra-abdominal and bloodstream) by quantifying SOFA scores and evaluating the requirements for organ support in the ICU (table 2).
To evaluate the requirement for CD8+ T cells in kidney transplant rejection, we studied class I-deficient (class I-) mice that had received vascularized renal allografts.
We previously established His-tagged mouse IZUMO1 transgenic mouse lines with Izumo1−/− background to evaluate the requirement for IZUMO1 in fertility [10].
In this study, we used the Ub fusion model to determine whether wild type mature Smac maintains a proapoptotic function after prolonged cytosolic localization, and evaluate the requirement of the IBM to induce apoptosis [37], [38], [39].
To evaluate the requirement for TERT for primitive hematopoiesis in zebrafish, we analyzed early hematopoietic markers in the anterior lateral mesoderm (ALM) which produces myeloid cells, and the posterior lateral mesoderm (PLM) that produces erythroid cells [53].
The findings that TNF-α is involved with the leishmanicidal activity and that NO is released in the co-cultures led us to evaluate the requirement for nitrogen and oxygen radicals in L. (L).
The lethality can be rescued by expression of AP2 components in the skin, which allowed us to evaluate the requirement for AP2 subunits at synapses.
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