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Further studies were designed with the aim of evaluating the induction of genotoxic and carcinogenic effects in Swiss albino mice exposed to smoke and/or light since birth.
We designed an experimental study aimed at evaluating the induction of possible noxious effects on testicular morphology and functions in A/J mice exposed whole-body to CS during the first 70 days of life, from birth to early adulthood.
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We also evaluated the induction of senescence in these cells by analyzing the expression patterns of senescence and stemness marker genes.
We evaluated the induction of corticospinal silent period (SP) using transcranial magnetic stimulation (TMS) at stimulation intensities normalized to resting motor threshold (rMT) or silent period thresholds (SPTs).
For example, for Amgen's candidate molecule ABP501, which is a biosimilar of adalimumab, an assay used Chinese hamster ovary (CHO) target cells (CHO M7, Amgen) to evaluate the induction of ADCC and CDC.
We then evaluated the induction of SOCS3 mRNA and protein levels in cells transiently transfected with HBx.
To evaluate the induction of FMDV-specific T cells as a result of vaccination, lymphoproliferation assays were carried out with PBMCs of vaccinated pigs.
Therefore we also evaluated the induction of both of these factors on the surface of DCs (Cd11cHigh, Cd11b-) derived from the spleens of Ad-GFP or Ad-GFP/rEA injected mice.
In order to study the involvement of the HR pathway in the repair of DSB resulting from Top2 poisoning we evaluated the induction of Rad51 foci at different times after treatment with both IDA and ETO in human fibroblasts.
To elucidate the participation of NHEJ in the repair of DSB induced by Top2 poisons we evaluated the induction of pS2056DNA-PKcs foci at different times after treatment with IDA or ETO.
As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01E and RTS,S/AS02D.
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