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Taken together with previous reports, the results of the present study highlight the importance of evaluating the functional role of genes by tissue-specific targeting, in order to clarify possibly contradictory findings that may stem from the compound effect of a gene's ablation in multiple tissues.
The model thus provides a tool for quantitatively evaluating the functional role of isoform-specific ion channel current on the generation and control of cardiac rhythm.
These results clearly demonstrated that the cell lines were valid for evaluating the functional role of HR proteins in DNA damage repair after nucleoside analogs.
Studies evaluating the functional role of immune responses against native ApoB peptides have shown that immunisation of hypercholesterolaemic mice with the p45 and p210 peptides inhibits the development of atherosclerosis, suggesting that it may be possible to develop ApoB peptide-based vaccines for the prevention of cardiovascular disease.
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Many studies are presently evaluating the functional roles of NO production in these settings.
This study aimed to characterize how inflammation regulates store-independent activation of Orai3-calcium influx and to evaluate the functional role of this influx.
The current study evaluates the functional role of the TcdA CROP-domain by utilizing truncated TcdA where the C-terminal amino acids 1875 2710 were deleted (TcdA1 1874).
To evaluate the functional role of TRPV4 in the endothelium, we performed pressure myograph experiments in CA from WT and TRPV4−/− mice.
To evaluate the functional role of NIX in MALM, we prepared NIX-knockdown cells using A549 and LS174T (A549 NIX-KD and LS174T NIX-KD, respectiveLS174T NIX-KD3).
To evaluate the functional role of Oct4 in t-hPSCs, we stably knocked down Oct4 by shRNA and then isolated fractions based on green fluorescent protein (GFP) (Figure S2).
In the absence of an agreed upon model to evaluate the functional role of these observed changes we propose that behavioral experiments comparing the localization performance of bats with an intact noseleaf and a deformed one e.g., lancet bent backwards, should be performed to verify whether the changes in the spatial sensitivity due to the lancet in M. microtis are behaviorally relevant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com