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If reproducible in other laboratories, the ADRB assay could prove to be an important new tool for evaluating the functional relevance of merozoite specific antibodies induced either by natural infection or vaccination with recombinant merozoite vaccine candidates [8], [29] [31].
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We focused on high-salt (5%and7 7% NaCl) concentrations to evaluate the functional relevance of the peptide under abiotic salt stress.
We therefore designed experiments to stress animals into borderline glycemic control conditions to evaluate the functional relevance of the aforementioned decreases in islet cell size and mass.
To evaluate the functional relevance of these repeats in strepsirrhines, we engineered a mutated murine amelogenin sequence containing a similar proline-rich sequence to that of Lemur catta.
To evaluate the functional relevance of this variability, 31 possible eIF4E/eIF iso 4E combinations were tested against Potato virus Y.
To evaluate the functional relevance of efficient or altered apoptosis signaling on NOD/SCID/huALL engraftment, we investigated apoptosome formation and function in xenograft samples.
Further studies are needed to evaluate the functional relevance of these CNVs and their effects on behavior, production, and disease resistance traits in goats.
Future studies should clarify whether poised enhancers are marked by the same chromatin signature in hESCs, mESCs and differentiated cell types, and evaluate the functional relevance of the Polycomb-mediated H3K27 methylation at enhancers.
To evaluate the functional relevance of HLA-E, we used the experimental setup described above and determined degranulation of NK cells expressing only the inhibitory receptor for HLA-E, i.e., NKG2A.
To evaluate the functional relevance of HLA for NK cell anti-myeloma alloreactivity, myeloma cell lines were co-cultured with NK cells from donors expressing all three inhibitory epitopes (i.e., HLA-C1+, HLA-C2+ and HLA-Bw4+).
With rapid progress in mapping regulatory elements and the growing availability of cell and tissue-specific gene expression data, future studies should be able to evaluate the functional relevance of genetic variants at 9p21.3.
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