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A valuable method for evaluating the functional effects of promising candidates in cardiac drug discovery is the analysis of electrophysiological characteristics.
Previous experiments evaluating the functional effects of PGs (most notably PGE2) on the β-cell have implicated PGs in the inhibition of glucose-stimulated insulin secretion from a hamster-derived cell line [ 44].
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The cells treated at similar conditions for 36 h were used for evaluating the functional effect of delivered antisense-miRNAs on target genes expression (PDCD4 and HoxD10) by TaqMan qRT-PCR.
To evaluate the functional effects of mediastinal radiotherapy, pulmonary function post-surgery but pre-radiotherapy was investigated and compared to the pulmonary function 1-3 years post-radiotherapy.
The aim of this study was to develop EGFR-targeted immunoliposomes for enhancing the delivery of CLX to cancer cells and to evaluate the functional effects of these liposomes in cancer cell lines.
Thus, the goal of this study was to evaluate the functional effects of the fusion of a CBM belonging to family 6, which exhibits high affinity to xylan, with the GH11 xylanase from Bacillus subtilis, which does not have a CBM in its wild-type form.
We therefore measured PARG enzymatic activity in the nuclear and cytoplasmic cell fractions to evaluate the functional effects of the antisense PARPG PMO treatment.
In this context and as previously described [29], in order to evaluate the functional effects of passive immunization treatment in mice, groups of non-tg and α-syn tg animals were tested in the water maze.
Having shown that JW74 exerts molecular effects on key mediators of the canonical Wnt signaling pathway, we next wanted to evaluate the functional effects of tankyrase inhibition.
Despite the conflicting evidence, currently, no studies have evaluated the functional effects of allergic airway inflammation that is characteristic of asthma on cancer progression in experimental models.
To evaluate the functional effects of the coiled-coil mutants on a longer timescale, we determined single-channel amplitude histograms (Fig. 7, G – I ).
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