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These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Aβ load.
These data will be useful for evaluating the functional consequences of missense MUTYH variants detected in patients with suspected MAP.
Careful experiments evaluating the functional consequences of specific dominant mutations are beginning to explain some of these differences [ 69– 71].
79 However, a recent study evaluating the functional consequences of all mutations found in Mc3r and Mc4r in severely obese North American adults concluded that Mc4r, but not Mc3r mutations are associated with severe obesity in this population.
Understanding the mechanism(s) that regulate plasma S1P levels and distribution of plasma S1P between protein-bound pools may therefore be important for evaluating the functional consequences of alterations in circulating S1P levels.
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However, further investigations will be required to evaluate the functional consequences of these findings and the biochemical function of most of the analyzed miRNAs, which remains elusive.
We then evaluated the functional consequences of Mia1p retention in the nucleus during interphase.
To evaluate the functional consequences of the thin myocardium seen in transgenic embryos, we used fetal echocardiography (Fig. 5H).
To evaluate the functional consequences of inhibition by TGF-ß, we examined the regulation PPAR-γ transcriptional activity.
To evaluate the functional consequences of manipulation of ZO-1 or ZONAB expression in RPE cells, we next assessed whether the changes in the RPE morphology lead to functional alterations by fluorescein angiography.
To evaluate the functional consequences of this deletion we performed a western blot on protein extracts from neural tissue of an affected dog and a healthy control dog to investigate whether the predicted longer mutant NDRG1 protein is expressed.
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