Sentence examples for evaluating the essentiality from inspiring English sources
In this work, we present an integrative computational method for evaluating the essentiality of components in signaling networks.
Aiming to overcome the limitations of existing structure-based approaches, we present an integrative computational method for evaluating the essentiality of components in signaling networks.
We have developed a generalized method to evaluate the essentiality of genes in Cryptococcus and applied it to the FKS1 gene.
We therefore proceeded to evaluate the essentiality of each RNR class during the infectious process, first constructing nrd mutants for each RNR class and then combining them to obtain double mutants (Materials and Methods).
More accurate experimental methods for knocking down/out genes in Drosophila are necessary to evaluate the essentiality of young genes.
As the expanded signaling network clearly represents the relationships among nodes and signaling interactions, we can evaluate the essentiality of a signaling component by examining the range to which its perturbation propagates.
In order to evaluate the essentiality of proteins in PPI networks, they are ranked in the descending order based on their ranking scores computed by ION in Section 2,5 as well as eight other existing centrality methods (DC, BC, CC, SC, EC, IC, NC and PeC).
To evaluate the gene essentiality predictions, we compared these to large-scale experimental data in vitro: in this case, a panel of cancer-specific cell lines derived from prostate adenocarcinoma (PC) or clear cell renal cell carcinoma (ccRCC), both cultured in defined serum-containing medium.
Both normal (VC/VO = 3) and stressed (VC/VO = 1) conditions during the rice photorespiration were simulated to evaluate the gene essentiality for cell growth by resorting to constraints-based flux analysis (see Method in Additional file 1).
This manipulation can be extended to include direct linking partners (check on the option "check first stage node"), saved, and re-submitted to cytoHubba to evaluate the node essentiality on the selected sub-network.
