Exact(7)
Due to the low computational cost of evaluating surrogate feasibility functions, this method can also be useful for flexibility analysis of processes described by computationally expensive models.
The possible role of these agents is based on animal studies and human studies evaluating surrogate coagulation markers.
Discussions in the literature on this subject have been frequently based on postulates for evaluating surrogate trial endpoints proposed in 1989 by Prentice.
Prentice developed a statistical criterion for evaluating surrogate outcomes in trials, 24 which requires that surrogate outcomes fully capture the treatment effect on patient-centred outcomes.
Investigators confirmed checkpoint pathway modulation by evaluating surrogate markers in tumour tissue treated with AZD7762, demonstrating decreased autophosphorylation of Chk1 at serine 296, and increased γH2AX.
Ten years ago, we suggested that it would be necessary and wise to directly assess the impact of our interventions on maternal mortality rather than solely evaluating surrogate measures [ 18].
Similar(53)
This is the first time the individual effects of four key factors; 1) choice of surrogate, 2) test features 3) study area, and 4) testing method have been considered when evaluating surrogates.
The agency would be required to set standards for how it will evaluate "surrogate endpoints"—measures of a patient's biological response to a drug that can indicate benefits more quickly than measures such as survival and disease progression.
This builds upon past studies that have only evaluated surrogate models for predicting peak surge, and provides the first system capable of probabilistically representing joint flood levels from TCs.
Variation in these results might reflect differences among studies in several key characteristics, such as, study area location, spatial extent, spatial resolution, type of surrogate, taxa (or other test features) used to evaluate surrogates, and analytical methods used to test surrogates.
The Institute of Medicine evaluation schema proved to give direction and focus to evaluating a surrogate marker.
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