Future clinical trials evaluating efficacy and side effects of topiramate in IIH would be of interest.
Randomised controlled trials (RCTs) have become the workhorse for evaluating efficacy of various healthcare interventions.
Active-control long-term monotherapy trials in newly diagnosed patients represent the mainstay for evaluating efficacy and safety.
The randomized controlled trial (RCT) is considered the 'gold standard' methodology for evaluating efficacy of an intervention.
Unfortunately the analytic tools for crafting control protocols employed in any particular setting do not necessarily translate equivalently between approaches, nor do the methods generally employed for evaluating efficacy easily translate to experimentally measured characteristics of the environment.
Given the acceptable safety profile of multiple intravenous Pexa-Vec infusions in patients with treatment-refractory colorectal cancer, further trials evaluating efficacy of intravenous Pexa-Vec, as monotherapy or in combination with chemotherapeutic agents, is warranted in this patient population.
Objective A double-blind, placebo-controlled dose-finding study was performed in 237 patients with predominantly unilateral knee osteoarthritis (OA) evaluating efficacy and safety of a new topical NSAID.
We discuss the rationale and design of ASCEND, the first large-scale randomized controlled trial evaluating efficacy of non-pharmacologic vs. pharmacologic treatment of depression in HD patients for patient-centered outcomes.
Future research should also be considered regarding the efficacy of exercise in preventing groin injuries and knee sprains, for these are also major injury burdens in male adult football and lack high-quality trials evaluating efficacy of preventive interventions [4,5,12,69].
There are no placebo-controlled studies of cannabis for headache disorders, although a multicenter, double-blind, placebo-controlled study evaluating efficacy and safety of a synthetic Δ9-tetrahydrocannabinol (THC), Dronabinol, in a metered dose inhaler for the treatment of migraine with and without aura has been completed, but results not available [66].
In evaluating efficacy, we surveyed 74 cases of 2- or 3-walled intrabony defect that satisfied the selection criteria.
