Sentence examples for evaluating compounds from inspiring English sources

The Bill and Melinda Gates Foundation recognized the scientific gap to delineate the spectrum of variables in experimental protocols, identify which of these are biologically significant, and converge towards a rationally derived standard set of optimized assays for evaluating compounds.

Using a human 11β-HSD1 selectinhibitoritor as a starting point, we designed and synthesized a new class of derivatives of 1-arylsulfonyl piperidine-3-carboxamides. It was found that the large lipophilic group on the amino moiety may lead to cross-species potency towards human and mouse, allowing drug development by evaluating compounds in rodent model.

Overall, our findings provide a platform for further evaluating compounds and strategies targeted at stimulating neurogenesis for treating or preventing AD in humans.

The Capan-2 spheroid model may be useful in evaluating compounds targeting the EGF signaling pathway.

Using this Locus Derepression assay, we queried 283,122 compounds by quantitative high-throughput screening evaluating compounds at multiple concentrations.

However, due to increased volume demands, applying such strategies to whole-organism drug discovery requires methods for evaluating compounds at HTS rates in vivo.

Thus, there is no current mechanism for evaluating compound volcanic impacts – e.g., the impact of a building first exposed to tephra fall and then several weeks later, exposed to lahar.

The predictions were then evaluated against an experimentally assessed "gold standard" generated by evaluating compound combination activity in vitro (M. Bansal et al., personal communication).

The cytotoxicity of all the evaluated compounds was evaluated against normal human skin fibroblast cells.

They found that almost all evaluated compounds showed a good correlation between their biological and predicted activities.

Among these evaluated compounds, compound T10 displayed a remarkable antiproliferative effect in vitro.