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Background: In vitro selection of viruses with decreased drug susceptibility is a useful tool for mapping drug resistance-associated alterations, evaluating cross-resistance profiles, and elucidating molecular mechanisms of antiviral activity.
This forms a likely upper bound for the frequency of at-risk couples as many of these presumed damaging variants may have no effect on protein function or disease risk, emphasizing the future value of experimentally evaluating their potential functional consequences and elucidating their real pathogenicity.
The aim of this study was to evaluate the effect and elucidate the potential mechanism of Bisebromoamide actions on human RCC cells.
High content screening of cell culture models continue to play a major role in evaluating therapeutic targets, elucidating aberrant pathways and identifying novel biomarkers.
Here, we assess C stocks in an ancient forest site at a stand which has not been managed for > 60 years and analyse the spatial variability of C concentrations and stocks to evaluate inter-annual variability and elucidate possible causes.
The vasodilator effects of these compounds were evaluated and the structure activity relationship was elucidated for the first time.
It was the first time for GC that the antitumor effect of EAC in vitro and in vivo were further evaluated and the possible mechanisms was elucidated by us.
We aimed to evaluate the direct antitumor effect and elucidate the potential mechanism of Bisebromoamide actions on human RCC cells.
Our results provided an animal model to evaluate burn-induced muscle wasting, and elucidate the underlying mechanisms.
Various rate models were evaluated to elucidate the kinetics of copper and zinc biosorptions, and the results indicated that the pseudo-second-order model was more appropriate than the pseudo-first-order model.
In this paper, the fragment-by-fragment thermal response of 16 porphyry copper ore samples following microwave treatment in the bespoke system is evaluated to elucidate key performance criteria and identify likely candidate ores for microwave sorting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com