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The accessions evaluated were obtained from the USDA-ARS Germplasm collection based on GRIN (Germplasm Resources Information Network, www.ars-grin.gov) data and with the assistance of the collection curator, Dr. Randall Nelson.
Firstly, the data on efficacy of the two therapeutic alternatives evaluated were obtained from a single clinical trial [ 10] so the differences in frequency and distribution of fungal species in real clinical setting could affect the efficacy results reported.
Gene signatures evaluated were obtained from the PAM50 (n=8 signatures) and claudin-low (n=1) subtype predictors (Parker et al, 2009; Nielsen et al, 2010; Prat et al, 2010); from the PAM50 predictor, we evaluated the correlation coefficient of each sample to each subtype centroid (luminal A, luminal B, HER2 enriched, BLBC and normal).
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First, the gene set of human and yeast pathways evaluated was obtained from KEGG.
In the present study, we evaluated lymphocytes, which were obtained from the same patients prior to and after vaccination, for changes in ζ-chain expression in parallel with monitoring the frequency of PSA-reactive T cells in the peripheral circulation and cytokine profiles of the T cells.
Data to evaluate the course were obtained from a baseline questionnaire administered to all first and second year students during mandatory medical school lectures or after scheduled examinations prior to the commencement of the course.
The naphthoquinones derivatives evaluated in this study were obtained from the lapachol, which was isolated by extraction from T. avellanedae sawdust [ 18].
All 44 rhesus macaque samples evaluated in this study were obtained from animals housed at the KCCMR in collaboration with researchers at this institution.
SNP data on the 374 accessions evaluated in this study were obtained from the SoySNP50K iSelect SNP BeadChip (Song et al. 2013) now curated on SoyBase (www.soybase.org).org
The amino acid sequences of the M. leprae proteins evaluated in this study were obtained from the Leproma website (available at http://genolist.pasteur.fr/Leproma/) and the SANGER CDS Retrieve Information (available at http://www.sanger.ac.uk/cgi-bin/yeastpub/get_cds?organism=M_leprae) [ 14, 16].
Of the 44 chimpanzee samples evaluated in this study, 34 were obtained from the Chimpanzee Biomedical Research Resource (NIH8U42OD011197-13), whish isupporteded through a cooperative agreement with the National Institutes of Health NIHH).
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