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Where a visual field defect was found, this was further evaluated using additional vectors with direction of target movement perpendicular to the boundary of the field defect.

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Performance of the population pharmacokinetic model was evaluated using 100 additional bootstrap replicates (re-sampling with replacement) of the data by fitting the final model to them.

The specificity of γH2AX and Chk1 phosphorylation as general biomarkers of Chk1 inhibitors was evaluated using three additional, structurally diverse Chk1 inhibitors: LY2603618 [ 11], MK-8776 (SCH 900776) [ 12] and GNE-900 [ 24].

Similarly, when evaluated using an additional publicly available lung cancer microarray dataset [ 31], we observe slight differences between the various pathways identified from analysis of differentially expressed genes derived from a NEPS-normalized dataset versus a dataset not normalized using the lung- NEPS genes (Additional file 9, Additional file 10).

All the Sanger reads were collected from the draft genomes (about 13,000 reads of 1000 nucleotides in length per genome on average) were aligned against the predicted ORFs of the CFN42 or CIAT652 genomes, and the alignments were evaluated using Polybayes (additional file 1 Figure S1), which determined the probability that a nucleotide site was polymorphic, based on the Phred quality of the read.

The quality of the LC-MS/MS data was again evaluated using Pep3D images (Additional file 3: Figure S3).

Model performance for these ENMs under the various climate change scenarios was evaluated using AUC values (Additional file 2).

The implementation of the project was evaluated using feedback forms (Additional files 1 and 2) after each phase of the project (audit or intervention).

To evaluate the cell cytotoxicity of the PFC/ICG nanoemulsion, three cell lines were exposed to various concentrations of the PFC/ICG nanoemulsion ranging from 0 to 100 μl/ml for 24 h or 48 h and were evaluated using an MTT assay (Additional file 1: Figure S3).

Correlation between biological replicates was evaluated using Pearson's correlation (Additional file 2: Table S10, Table S11).

Some of the potential networks and pathways were also evaluated using the PathwayAssist program (Additional files 4 and 5).

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