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At the final follow-up, functional outcome was evaluated using a modification of the clinical grading system developed by d'Aubigné and Postel [10].
The methodological quality of papers was evaluated using a modification of the Newcastle-Ottawa scale.
Similar to the in vitro studies, the extent of apoptosis in the in vivo model system described above was evaluated using a modification of the TUNEL immunohistochemistry method previously described by Aboagye et al (1998).
Smoking exposure was evaluated using a modification of the European Prospective Investigation into Cancer EPICC) study questionnaire (Sargeant et al, 2001), and individuals categorised as never, former and current smokers.
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Statistical significance of effect-measure modification was evaluated using a LRT and based on the continuous acrylamide intake variable.
The antibacterial activity of LDs was evaluated using a CFU assay as described previously (Figueredo et al., 2009) but with a slight modification of the conditions.
Ferrous ion chelating activity was evaluated using a standard method [ 18] with minor modifications.
Densitometric measurement of intra-tumoural enhancement was performed using a modification of the Choi Criteria to evaluate the effect of the treatment course on tumour viability.
Mitochondrial protein quality was evaluated using an unrestricted survey of post-translational modifications (PTMs) of the mitochondrial proteins that were detected by mass spectrometry.
Biocontrol efficiency was evaluated using a gnotobiotic sand system (Simons et al. 1996), with minor modifications.
HRCT studies were evaluated at five predetermined levels using a modification of a semiquantitative HRCT scoring system previously described [ 26].
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