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Employing a single CpG look-up approach (one CpG evaluated, uncorrected for multiple testing), our data provide support for an association between maternal smoking during pregnancy and cord blood DNA methylation at this CpG (coef = –0.020, se = 0.009, p = 0.016).
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To evaluate uncorrected near visual acuity (NVA), accommodation, corneal aberrations, and the optical quality of the retinal image in presbyopic eyes after photorefractive keratectomy (PRK).
We aimed to evaluate uncorrected distance visual acuity (UDVA) as an outcome in treating astigmatic cataract patients to assist clinicians or ophthalmologists in their decision making process regarding available interventions.
Parameters evaluated were uncorrected and best corrected visual acuity, specular microscopy, intraocular pressure and pachymetry both preoperatively and postoperatively on day 1, 1 week, 1 month and 3 months and development of any complication both intraoperative and postoperative were also noted.
Simple effect SPMs (for within material type comparisons) were similarly evaluated under an uncorrected threshold of p < 0.0005 and a minimum cluster size of 5 contiguous voxels.
For activation, which was evaluated at an uncorrected p-value of <.001, cluster threshold correction was applied as a threshold larger than 12 voxels corresponded to a corrected alpha level <.05 with our parameters given.
Simple effect SPMs (for within-group comparisons) were similarly evaluated under an uncorrected threshold of P < 0.001 and a minimum cluster size of 5. Maxima of significant clusters were localized on individual normalized structural images.
All main effects of condition (across groups) and group-by-condition interaction SPMs were evaluated under an uncorrected alpha level of 0.001 and a minimum cluster size of 5 contiguous voxels.
a P value, uncorrected for multiple tests.
However, in view of the scarcity and novelty of memory-related intrathalamic data in humans, a highly conservative approach to evaluating these observed uncorrected p values was taken.
With the highest cut-off values, the uncorrected protective effects evaluated by BED, AI and BED-AI were 50% (95%CI: 27% to 66%, 500%21%to69o 69%) and 63% (36%to81%1%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com