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In this study, different Nef DNA and protein constructs were generated, and their abilities were evaluated to induce T cell immune responses and humoral immunity in mouse model.
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The 12 glycopeptides evaluated were found to induce different T-cell response profiles (Table 1 and File S1).
To determine whether MPs are biologically active, we evaluated their ability to induce BAFF release by activated RA FLSs.
We evaluated its feasibility to induce exon skipping and downregulate MSTN expression in myotubes cultures and DMD mouse models.
We analyzed TN-C expression in normal and osteoarthritic (OA) human cartilage, and evaluated its capacity to induce inflammatory and catabolic mediators in chondrocytes in vitro.
These epitopes were synthesized to evaluate their ability to induce TCD4+ lymphocyte proliferation in mice.
Regardless of which approach eventually proves to give the best protection for TB, robust tools for evaluating their ability to induce protective immunity are also required.
Furthermore, we produced and purified Z-eGFP derived VLPs to evaluate their ability to induce an immune response in vivo.
Similarly, constitutively active mutants were expressed in a non-transformed human fibroblast cell strain to evaluate their potential to induce malignant transformation.
To evaluate the ability to induce apoptosis in each clone, we collected cultured cells at 24, 48, and 72 h after Dox treatment and analyzed the DNA histogram by flow cytometry.
The 14 synthesized compounds were evaluated for their ability to induce efflux of glutathione (GSH) from tumor cells overexpressing MRP1.
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