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No biomonitoring studies evaluated this pathway.
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While we realize that primary hepatocytes would be a better model to evaluate this pathway, we choose the HepG2 cell line as an means to evaluate this phenomenon but allowing for use of the known anti-cancer effects of TSA as a control.
Several epidemiologic studies have evaluated this hypothesized pathway using residential proximity to landfills as a proxy for exposure.
Dietary exposure to pesticides can occur via both food and water, and no studies have systematically evaluated this specific pathway for contribution to overall farmworker exposure.
We then evaluated the pathways of fatty acid biosynthesis, fatty acid elongation, and fatty acid metabolism during PED.
Indeed, isoprostanes are currently considered the gold standard biomarker of OxS and lipid peroxidation in vivo (3) and may provide a better opportunity to evaluate this important lipid peroxidation pathway in the pathophysiology of vascular diseases.
We did not observe sufficient numbers of SSc cases to evaluate this disease by asbestos exposure pathways.
Gene ontology, biological networks, and canonical pathways were evaluated with Ingenuity Pathway Analysis software (www.ingenuity.com) and the DAVID Annotation Tool website (http://david.abcc.ncifcrf.gov) [7], [8].
To test this, we evaluated pathway changes that occurred between 2h and 4h of activation.
To explore this, we evaluated cellular inflammatory pathway activation in terms of phosphorylation of the mitogen-activated protein (MAP) kinases p38 and ERK1/2, p38's immediate downstream substrate MAPK-activated protein kinase 2 (MK2), and the transcription factor NF-κB, during the first few minutes of VILI.
To build the classifier, we evaluated each pathway based on the discriminative power of its activity score to classify samples.
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