The aim of this work was to re-evaluate the previously obtained transcriptional response in thyroid after administration of 131I− and free 211At in mice from different exposure conditions to gain a better understanding of variations in transcriptional regulation on absorbed dose, dose rate, time after administration and radiation quality.
These same tablet formulations were also evaluated previously by a human scintigraphy study, and the results were exactly opposite of those obtained using the in-vitro porcine model.
In addition, we also evaluated previously proposed regression models by various authors with the same and/or similar variables as those obtained in our current study.
The validity of these questions has been evaluated previously [29].
The matrix effect was then evaluated for concentrations around those previously obtained, using five matrix-matched 226Ra standards, with increasing concentrations of Ca (1, 2, 5, 10, and 20 μg g−1) and Mg (0.25, 0.5, 1.25, 2.5, and 5 μg g−1), and comparing them with a standard without Ca and Mg, at the same 226Ra concentration (27.5 fg g−1).
To evaluate the proposed method, it was compared with previously obtained results of the experiments and calculations carried out with the help of BS8006, Giroud, Perrier, R.A.F.A.E.L methods and PLAXIS and Sofistik programs.
We compared the targeting efficiencies in these lines with those previously obtained with ES cells of other species, and evaluated the differentiation potential of correctly targeted clones, to assess the feasibility of gene targeting in the rat using ES cells.
The values were ultimately determined by adjusting the pre-designed model to the experimental results previously obtained with mice, in which thymocyte development was evaluated during thymus recovery following sub-lethal γ-ray irradiation [24].
From this assumption, the activity herein presented starts from experimental results, previously obtained, that analysed the influence of non-Gaussianity (generally evaluated by kurtosis) and of non-stationarity of inputs on the fatigue life of an Y-shaped specimen.
In this regard, previously obtained outcomes and conventional safety levels are used to evaluate reliability of presented conclusions.
