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The safety and efficacy of Seprafilm in abdominopelvic laparotomy were initially evaluated in two randomized controlled multicenter clinical trials.
As detailed above, this question has now been evaluated in two randomized trials [ 11, 12].
The latter two approaches are being evaluated in two randomized studies against WBRT in Europe.
The safety and efficacy of ecallantide were evaluated in two randomized, double-blind, placebo-controlled trials (EDEMA3 and EDEMA4) in 168 patients with HAE-C1-INH.
47 The immunogenicity of PCV13 in the elderly was evaluated in two randomized multicenter studies (unpublished) conducted in the United States and Europe.
In patients without sepsis but with systemic inflammation, the effect of HVHF on mortality was evaluated in two randomized controlled trials [ 34, 35].
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Sibutramine efficacy in weight loss maintenance has been evaluated in three randomized controlled studies.
The efficacy and safety of LDX in the treatment of ADHD were evaluated in six randomized, parallel-group, double-blind, phase III trials (Table 1) [ 23– 28].
The addition of colesevelam to established antidiabetes monotherapy or combination therapy with metformin, sulfonylureas or insulin in patients with T2DM was evaluated in three randomized, double-blind, placebo-controlled clinical trials [ 26– 28].
Sipuleucel-T was evaluated in three randomized phase III studies [D9901: NCT00005947; D9902andNCT01133704; and Immunotherapy for Prostate Adenocarcinoma Treatment (IMPACT; D9902B): NCT00065442] of patients with asymptomatic or minimally symptomatic mCRPC, and consistent improvements in OS, compared with placebo, were observed across the studies [ 5, 12, 13, 16].
The use of ATBs in VAT has been evaluated in two recent randomized controlled trials.
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