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Pulmonary metastatic tumors were microscopically evaluated in the largest cross sections.
Edoxaban is the newest factor Xa inhibitor that has been evaluated in the largest randomized controlled trial of all NOAC trials.
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Several prototype devices with bialkali photocathodes have been fabricated with the described system and their characteristics were evaluated in the large signal (multi-PE) limit.
The time-to-response during lenalidomide therapy was evaluated in the larger of the two pivotal clinical trials [ 8].
The clinical utility of this assay is being prospectively evaluated in the large, randomised MINDACT trial that enrolled 6690 EBC N0 N3 patients [28].
3q26 also exhibited good performance for high-grade and cancer cases and was further evaluated in the larger set of biopsy samples.
The potential effects of coadministered P-gp inhibitors on the clinical efficacy and safety of edoxaban will be further evaluated in the large-scale phase 3 Hokusai-VTE and ENGAGE AF-TIMI 48 studies.
Limitations of the present study include the fact that the sensitivity of self-report anhedonia questionnaire has not yet been evaluated in the large clinical samples, additional studies will also be needed to assess whether the SHAPS scale may be useful for distinguishing patients with different psychopathological disorders.
Although two of the ICS genes are derived and subsequently prioritized from these datasets, thus biasing us towards a positive finding, we note that the IR-7 signature from which three of the ICS genes (HLAF, TNFRSF17, XCL2) were derived was not significantly prognostic when similarly evaluated in the larger of these microarray datasets (n = 199, P = 0.08).
The variable size of the counties leads to fewer possible cluster locations evaluated in the area of large counties.
Finally, as both genetic and phenotypic heterogeneity appear to be an emerging theme in many genetic disorders, it is clear that WES data should be evaluated in the context of large cohorts of patients and controls [ 33].
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