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Other enzymes have been recently evaluated in relationship with methadone metabolism: CYP2C19 and CYP2C9.
Therefore, LV systolic function should be evaluated in relationship with LV afterload, explaining the common use of Ees/Ea as primary parameter for LV systolic function [ 7– 11].
Even in chemotherapy, the drug concentration in one cancer cell is impossible to determine because of tumor heterogeneity; consequently, the true intracellular drug concentration cannot be evaluated in relationship with its efficacy at present.
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This relationship has not been evaluated in persons with chronic kidney disease (CKD), a condition associated with increased risk of both retinal pathology and cognitive impairment.
We selected the time periods to coincide with the self-reported interview data on pesticide use (1 year), the upper limit that we judged the crop maps to be representative of actual cropping patterns (2 years), and the time period most associated with concentrations of pesticides in house dust (180 days) in the previous study that evaluated the relationship with CPUR data (Harnly et al. 2009).
We evaluated the relationship with salmon abundance which fluctuated from ~3000 in the late 1990s to ~30,000 in the late 1940′s.
AEs were classified according to system organ class and preferred term (MedDRA/J version 13.0) and were evaluated in terms of their potential relationship with the study drug (no causal relationship or possible causal relationship) and severity (mild, moderate or severe).
The steady-state force-[Ca2+]i relationship was evaluated in LV trabeculae treated with 5 μmol/L of ryanodine, a plant alkaloid considered to block ryanodine receptor channels to generate a long-lived subconductance (half-open) state [ 55] and eventually to deplete the sarcoplasmic-reticular calcium stores.
Our objective was to determine the risk factors for bone fragility evaluated by BMD and fracture prevalence in sarcoidosis patients and in particular to evaluate the relationship with vitamin D and calcium metabolism in a pilot cross-sectional study.
Owing to its interesting chromosomal localisation and its potentially EGFR-inhibiting qualities, we found it of interest to examine the expression of LRIG1 in RCC and to evaluate its relationship with the expression of EGFR, in RCC and in normal kidney tissue from the same patients.
Data regarding the relation between maspin expression and clinico-pathological parameters need to be further confirmed on a larger scale with a longer follow up of patients in order to evaluate its relationship with clinical outcome including OS, disease free survival as well as tumor recurrence (Table 9) [129].
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