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This process has yielded several potential novel targeted 225Ac-labeled immunotherapeutic agents that may now be evaluated in appropriate model systems and ultimately in humans.
The effects of modulating TRPM7 expression and/or activity using small molecules, either in isolation or in combination with cytotoxic chemotherapeutic agents and other targeted therapeutics, should be evaluated in appropriate tumor models.
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Our reported evidence on multiple effects induced by D609 on HER2 downmodulation from the plasma membrane suggests the interest of further evaluating in appropriate model systems the added value of including a PC-PLC inhibitor as an adjunct to the current therapies targeted against HER2-overexpressing breast cancer cells.
The number of mares and stallions used is too small, too few mares are inseminated at the appropriate time using adequate AI doses, too few semen samples are evaluated in an appropriate manner from each male, and the fertility data of mares is inaccurate [ 11].
However, the national debt must be evaluated in an appropriate manner, such as comparing the amount of interest expense paid to other governmental expenditures or by comparing debt levels on a per capita basis.
Subsequently, this must be evaluated in an appropriate outcome trial.
As the relation between temperature and health may change over time and space, it needs to be evaluated in an appropriate way.
It is also essential that the results of treatments are evaluated in an appropriate manner that reflects the translational relevance of the animal model and is not potentially subject to other interpretations.
In this regard, potential biomarkers should also be evaluated in more appropriate control conditions that can mimic ALS, the exclusion of which causes regularly diagnostic delays during early disease stages, when patients present with only upper or lower motor neuron signs [ 106].
The results of simulations made with EnergyPlus are evaluated in terms of appropriate thermal comfort criteria and subsequently potential reductions in plant energy consumption so that the most effective strategies to mitigate the energy consumption associated with air-conditioning processes.
The instructions are fairly specific: "All applicants," writes NIH, "should be evaluated in a manner appropriate for the present stage in their careers".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com