A therapeutical approach already evaluated for humans using animal models, such as the ex vivo gene manipulation of myogenic stem cells for treatment of myopathies represents another potential future application [ 47- 49].
But of the 84,000 industrial chemicals registered for use in the United States, only about 200 have been evaluated for human safety by the Environmental Protection Agency.
"Her exceptional judgment in evaluating a new drug for safety for human use has prevented a major tragedy of birth deformities in the United States," said President John F. Kennedy in 1962, as quoted in an obituary in The New York Times, when he presented her the President's Award for Distinguished Federal Civilian Service the nation's highest civilian honor at a White House ceremony.
Nonetheless, the steady rise in the number of alternative conduits and scaffolds made from synthetic and/or natural polymers and with different structures and topographies dictates that at some point the critical step of evaluating biomaterials intended as nerve guides for human use must be made.
The results obtained here have important implications not only with respect to the design and engineering of liposomes for human use, but for evaluating the therapeutic efficacy of liposomal formulations in experimental animal models as well.
Existing drugs have known safety profiles and are approved for human use, so they can be rapidly evaluated for new indications.
Some of these have already been approved by the FDA for human use, and many are currently being evaluated pre-clinically or in clinical trials.
For evaluating strategies for improving gene expression, in vivo reporter imaging technologies with potential for human use, such as those that are SSTR2-based, are useful.
They were never intended for human use.
Estetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans.
