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Positive control conditions that were specific to the evaluated endpoints were often described.
Neither the 3.0 µm nor the 9.6 µm microspheres had any significant effect on the evaluated endpoints [145].
However, evaluated endpoints were non-specific acute toxicity and mortality, which provided only minor contribution to the overall study outcomes.
Regarding evaluated endpoints, while acute toxicity brought limited information, the assessment of specific endpoints was of strong value for bioactivity identification.
Not all trials reported findings on all evaluated endpoints.
Interpreting data from biomarker studies is confounded by differences in study design, inclusion/exclusion criteria of patients, duration of treatment, time of sampling and laboratory evaluation, as well as differences in evaluated endpoints of treatment, making it difficult to compare studies in a systematic review or a meta-analysis in a meaningful way.
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5, 17 Despite this observed impact on patients, quality of life is not a commonly evaluated endpoint in rosacea.
A task force to further evaluate endpoints in oncological diseases, and survival endpoints in particular, under the auspices of the German Association of Research-based Pharmaceutical Companies (vfa) was appointed.
The EDA investigations guided only by zebrafish bioassays followed either a single test setup (e.g. [36,53,55-57]) or a combination of methods (e.g. [44,52]) to evaluate endpoints in zebrafish.
These results indicate some husbandry factors affect growth, sexual maturation and egg production in medaka and should be taken into consideration in studies evaluating endpoints that may be impacted by growth and reproductive performance, i.e. carcinogenesis and endocrine disruption studies.
This improvement was not associated with an increase in the proportion of motile sperm (p = 0.12), providing further evidence that it is essential to evaluate endpoints other than sperm survival and motility when optimizing cryopreservation methods.
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