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Product-related factors, patient-related factors, and treatment-related factors, which may contribute to the immunogenicity risk profile of a biotherapeutic (Koren et al., 2002), were thoughtfully evaluated during the development cycle of InO ADC.
Although the assays developed are specific for ONNV and CHIKV, different assay designs, detection strategies and chemistries were evaluated during the development process and those results are also reported here.
We also included the Preliminary CCL (PCCL) listing of the 528 chemicals that the U.S. EPA evaluated during the development of draft CCL3 (U.S. EPA 2008d).
As the aim of this study is not to provide a new subtyping method for S. Typhimurium, but to elaborate on important parameters to be evaluated during the development of a MOL-PCR assay, the sequences of the probes and primers used are less relevant for the key message of this paper.
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We also considered the relationship between sample size and number of items, since this is considered an important methodological aspect to be evaluated during the scale development process.
Other goodness-of-fit plots, such as conditional-weighted residuals versus time and population prediction were also evaluated during the model development for gemcitabine, dFdU and dFdCTP.
28, 29 In addition to the treatment of VVA, other targeted indications evaluated during the Phase II development of ospemifene included postmenopausal osteoporosis, treatment of menopausal symptoms, and cardiovascular disease.
Transporters are widely expressed in various human tissues and are routinely evaluated during the process of drug development and approval.
It's thrust force, efficiency of characteristic velocity, and specific impulse were evaluated during the course of it's development.
Software architectures should be evaluated during the early stages of software development in order to verify whether the non-functional requirements (NFRs) of the product can be fulfilled.
Inview of this, a sensitive and specific mass LC-MS/MS technique in MRM mode wasevaluated for the quantification of SHH and MAP PGIs in celecoxib drug substance.Then, the possibility of using electrospray ionization (ESI) source under positiveion detection mode was evaluated during the early stage of method development.
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