With regard to studies that did not contain a randomized controlled design, the following aspects were evaluated: definition of study population, selection bias, intervention description, outcome definition, blinded outcome assessments, completeness of the dataset/follow-up, loss to follow, confounders, and a judgment of the validity and applicability of the study.
The evaluated definitions were dichotomized after analysis of design, agreement and prevalence: insulin measurement requiring definitions (WHO and EGIR) and definitions not requiring insulin measurement (NCEP, ACE, IDF).
The numbers and percentages of FPs and sFNs obtained with each of the 11 evaluated definitions are shown in Table 3.
Evaluation of the definition generation: to evaluate definition generation, for 500 GO and 500 MeSH terms 10 definitions were generated and manually labelled as either correct if they match the GO/MeSH definition or valid if they were at least sensible and relevant.
We evaluated clinical heterogeneity (diversity) among the trials by abstracting data on included populations and evaluating definitions of outcomes (often not reported).
Additionally, in a study evaluating definitions of clinical worsening as a predictor of proximate (within 1 year) risk for subsequent major events (ie, death, transplantation, or atrial septostomy), hospitalization was independently associated with poor survival: the 1-year survival rate in patients hospitalized was only 71.4% ± 1.5%.
Two definitions were evaluated; RP definition A: An average eGFR decline (slope) ≥5 m/year/1.73 m/year over four years of follow-up with ≥3 eGFR measurements/year, last eGFR <90 ml/min/1.73 m and an absolute decline ≥5 m/year/1.73 m/year in two consecutive years.
For quantification of this phenomenon, the probability density function of flame curvature was evaluated with definition of the mean curvature radius as representative folding scale.
Regarding the response to the TB Antigen of the QFT-IT format, we found that the sensitivity of IP-10 for detecting active TB was similar to what was reported for the QFT-IT response (evaluated by definition by IFN-γ .However, dIFN-γ .Howeverm QFT-IT, the IP-10-medifferentlyonse was not dependent on the CD4+ T-cell counts and Ifrom mitogen response.
Risk score assessment was evaluated by definition of clinical and cut-off point of laboratory investigation.
