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Across all evaluated data sets, we find that incorporation backbone sampling improves accuracy substantially, irrespective of using a crystal or NMR structure as the starting conformation.
To test the validity of this algorithm, it was applied to simulated and real jitter measurements from control subjects and patients with myasthenia gravis, and to nerve conduction studies from patients with various conditions referred for EDx studies.There was good concordance between E-Ref and RVs for all evaluated data sets.E-Ref is a promising method to develop RVs.
In addition, they evaluated data sets from six population based cohorts [ 43].
On the evaluated data sets, IFR demonstrates that at least 20 iterations are required before we see a significant loss in discriminatory power, providing hundreds of genes for further analysis.
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The fuzzy k-means fuzziness factor determines the degree of overlap between the generated clusters and analysis of the evaluated data set found that a value of 1.05 generated well-defined and differentiated clusters.
The distribution of each of these characteristics in the EREG evaluated data set was also similar to that observed in the total study population.
While E. coli total tRNAs were used to develop this exclusion list strategy and L. lactis total tRNAs served as a previously evaluated data set to confirm the general characteristics of this approach, a more fruitful application would be for RNA modification mapping of bacteria that are presently uncharacterized.
Furthermore, the cell cycle cluster of genes (PC1 for each data set) was as effective as all of the other established classifiers we examined when used to evaluate data sets other than those from which they were derived (Table 2) [see Additional file 2].
The characteristics and a short description of the medical meaning of the evaluated data-sets are summarized in Table 1.
The results are displayed as the mean, minimum and maximum number of different trees constructed on the 8 evaluated data-sets and are within an accuracy class.
Number of diverse trees with an improvement in relative accuracy of [ min%, max%] compared to the CART tree, displayed as mean(min, max) referring to the mean, minimum and maximum number of trees constructed on the 8 evaluated data-sets.
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