The results of a simulation study showed that, compared with a specific 3+3 design, this 'up-down' dose-escalation design allows more patients to be evaluated closer to the MTD and fewer at toxic dose levels (see Supplementary Materials).
The simulation study also demonstrated that, compared with a specific 3+3 design, more patients are evaluated closer to the MTD and fewer patients at toxic dose levels using the 'up-down' design.
Therefore, we also performed comparisons of RMIP values for joint-family analysis conducted with P=0.01 threshold and single-family analysis conducted with P=0.0001, since it was the threshold evaluated closest to the Bonferroni-corrected P-value of 0.01/25.
Alternatively, differences among case group–specific associations might be attributable to exposure being evaluated closer to first reported diagnosis of depression for PRE-E and PRE-B cases than for POST cases, which could be particularly important for pesticides, such as organochlorine insecticides, with marked secular trends in use.
By further increasing (beta), we reach a situation where the second term always evaluates to a value close to 0 if the speaker's social status is smaller than the listener's social status.
The relatives of the survivors were more satisfied in all dimensions evaluated (a value closer to greater satisfaction), although this difference was statistically significant only in the comfort dimension (P = 0.003).
In an initial study we evaluated closed loop delivery after a medium sized evening meal, mimicking an evening at home when closed loop delivery could be conveniently started with the meal.
A realistic field monitoring application to evaluate close proximity tunneling effects of a new tunnel on an existing tunnel is presented.
The results are promising: the recommendations were positively evaluated and close to those coming from state-of-the-art metadata-based systems, and the subjects judged the generated visualizations to capture their core preferences.
This could be due to the fact that the range of pretreatment conditions evaluated was close to the optimum for CSY.
Γ has a range of (0, 1] to evaluate the fairness; the value closer to 1 refers to better performances of fairness. The index shown in Equation (5) can be used to assess both the per-flow fairness and weighted fairness.
