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The ability to identify patients responding or not to VE (ΔveCO ≥ 15%) was evaluated by calculation of the areas under the receiver operating characteristic curves (AUCROCs).
In addition, the UV-C dose was evaluated by calculation of the theoretical maximum UV-C energy input and actinometric measurements using iodide/iodate actinometry.
The significance of the changes in CEC values for ground samples compared to ground and wet sieved with 106 µm cutoff was also evaluated by calculation of P values using Student's t Test (Additional file 1: Table S5).
The predictive performance of both models was evaluated by calculation of the true positive fraction (TPF, or sensitivity) and of the false positive fraction (FPF, or specificity).
The activity of disease was evaluated by calculation of 28-joint Disease Activity Score (DAS28) [ 34].
Disease severity was evaluated by calculation of the Sequential Organ Failure Assessment (SOFA) score [ 12].
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Bias and precision of the estimated population parameters were evaluated by calculation and comparison of relative bias (RBias) and relative standard deviation (RSD), for each population parameter (i), under each method for handling the missing data (j; plus estimations using all data) and under each missing data mechanism (k).
Results: In suspension, BAE exhibited, in our experimental conditions (3×106 cells per ml), a spherical size evaluated by calculation at a mean radius of 7±2 μm.
The LD50 value of the essential oil solution was evaluated by calculation [ 20].
These options were evaluated by calculations.
Comparisons between DASs at similar time points from different courses were evaluated by the calculation of differences of means and paired t tests.
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