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ERBB2 was first evaluated as a target for trastuzumab therapy in invasive breast cancer, and later in gastric cancer and EAC (Huober et al, 2006).
After its development as a therapeutic target for patients with breast cancer, HER2 has been evaluated as a target for patients with other tumor types.
In addition to being proposed as a marker for liver tumor diagnosis, GPC3 has also been evaluated as a target for antibody- and cell-based therapies of HCC [ 18].
Of particular note, AP-1 appears to be overexpressed in breast cancer [ 44, 45], and is currently being evaluated as a target for molecular therapy in this disease [ 46- 48].
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In the future, CD44 should be evaluated as a potential target for epigenetic therapy and as a target for antibody-based therapies in CD44+ lymphoma subtypes.
Accordingly, PDF has been evaluated as a drug target; however, architectural mechanism studies of PDF have not yet fully elucidated its molecular function.
Moreover, in BRCAX patients, XRCC1 could be evaluated as a molecular target.
MAT-2β has to be evaluated as a possible target to improve prognosis in the t(12 21) ALLs (Table 3).
The aberrant expression of ANXA2 in differentiation and metastasis may be evaluated as a potential target for clinical biomarkers after a large, properly controlled clinical study.
Of the three main functions of the Ang/Tie system, it is mainly angiogenesis that has been evaluated as a therapeutic target.
Although, the TGFβ pathway is being evaluated as a therapeutic target in gastric cancer [ 28, 29], the complex roles of TGFβ in tumor progression might make it difficult to select the patients that will benefit from an anti-TGFβ therapy.
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