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This ability was evaluated as a second aspect of the overall virulence.
To further investigate the protective effects of SurR9-C84A, LDH release was evaluated as a second indicator of toxicity.
LSU-Lb was further evaluated as a second divergent plasmid carried by this species.
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When dronedarone was evaluated as a second-line treatment option, the comparators were the antiarrhythmic drugs amiodarone, sotalol, and class Ic drugs, depending on the type of AF and baseline risk factors.
Switch maintenance chemotherapy using S-1 is also being evaluated as a first-line chemotherapy for patients with advanced NSCLC in a phase II study (UMIN000003676).
Due to their efficacy and safety, the new generation of FQ's is even being evaluated as a first-line medication for tuberculosis [ 27- 29].
Bendamustine plus rituximab (B-R) is a new immunochemotherapeutic regimen with high activity and low toxicity in relapsed and refractory FL [ 37] that is being evaluated as a first-line therapy.
Troxacitabine was recently evaluated as a first-line therapy in 54 patients with advanced adenocarcinoma of the pancreas and gave comparable overall results to those reported with gemcitabine in recently published randomized trials.
The results of a randomised phase III trial evaluating, as a first-line treatment for HER2-negative MBC patients, the combination of paclitaxel and bevacizumab vs paclitaxel alone have been published recently (Miller et al, 2007).
27 Ofatumumab was first evaluated as a monotherapy in a phase I/II trial on heavily pretreated patients with relapsed/refractory CLL.
ERBB2 was first evaluated as a target for trastuzumab therapy in invasive breast cancer, and later in gastric cancer and EAC (Huober et al, 2006).
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