Sentence examples for evaluated affinity from inspiring English sources
The ligands with the best evaluated affinity are selected as lead candidates for drug development.
To properly select prediction thresholds for the models, we experimentally evaluated affinity of 64 predicted FoxA BSs using EMSA that allows safely distinguishing sequences able to bind TF.
This study proved a possibility of a peptide probe for evaluating affinity properties of proteins.
Static and dynamic binding and selectivity experiments were performed in order to evaluate affinity and selectivity of the polymeric matrices for the template and molecules from the same family, benzamide and pivalamide.
The data quality precluded evaluating affinity constants for the weaker interactions, but sulfate and selenate were measured at 34.4 and 23.8 M–1, respectively.
This opens the way for similar quantitative approaches to be used to evaluate affinity and efficacy measures for different VEGF isoforms in mediating responses via other signalling cascades.
DCAs were used to evaluate affinities and differences between species and stations to avoid the arc-shaped distribution when there is a single strong gradient affecting the samples (Gauch 1982).
Furthermore, we evaluated the affinity of aggrecan for gelatin by atomic force microscopy and radiolabeling experiments.
The ligands synthesized were evaluated for affinity and selectivity by radioligand displacement and a functional steady-state GTPase assay.
The 3 labeled Nanobodies were evaluated in affinity measurements, and paired-label internalization assays were performed on HER2-expressing BT474M1 breast carcinoma cells and in paired-label tissue distribution measurements in mice bearing subcutaneous BT474M1 xenografts.*I-SGMIB-Nanobody was produced in 50.4% ± 3.6% radiochemical yield and exhibited a dissociation constant of 1.5 ± 0.5 nM.
To determine if the activity of ALN was retained following polymer-conjugation, we evaluated the affinity of the conjugate to bone mineral by in vitro HA binding assay.
