The multi-institution study described here has evaluated TIP given at modified dose in a salvage setting to all prognostic groups and has compared the results with the MSKCC salvage chemotherapy experience.
After an impressive pathological response of 34%, the investigators of SNAP (Studio Neo-Adjuvante Portio) proceeded to a phase II randomised study of neoadjuvant chemotherapy evaluating TIP vs the doublet of ifosfamide cisplatin (IP), and illustrated the superiority of TIP vs IP with an optimal pathological response (OPR) of 48 vs 22%, respectively (Buda et al, 2005).
A secondary contribution of our work is a method for automatically evaluating tip-mining algorithms without humans in the loop.
The purpose of our study is to evaluate different tip shapes ease of insertion compared with the conical shape.
The Fredholm integral equation, proceeding from the dual integral equations, is numerically solved to evaluate crack tip stress intensity factor.
Silicon tips with a radius of 10 20 nm, spring constant of 0.3 N m−1, and resonance frequency of 250 300 kHz were used after the calibration with gold nanoparticles (diameter: 5.22 nm, Pelco AFM Gold Standard Kit). to evaluate the tip radius.
Similarly, work has been done to evaluate the tip-over impact performance of dry cask storage structures.
When evaluating the unilateral pelvic lift, it was important to stand on the same side as the supported leg and to be in line (eye level) with the patient's hip to be able to evaluate any tipping of the pelvis and at the same time to have some reference line beneath the patient by which to register any lowering of the pelvis.
In a more recent randomised phase II study of the same group evaluating neoadjuvant TIP vs TP, aiming towards radical surgery in chemotherapy- and radiotherapy-naive patients, the incidence of grade 3 4 neutropenia was 76% for TIP vs 26% for TP without routine prophylactic G-CSF (Lissoni et al, 2009).
The digital image correlation (DIC) technique was used to capture and evaluate the crack tip strain fields and crack closure variation; the results showed that the strains near the crack tip become larger and the crack opening load increases after the application of the OL.
